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The MS/MS spectra for different peptides are shown in Determine three(C) and Figure S2. PY03971 has 4 interior repeats and proteolytic processing can yield four fragments, of which two have the sequence of ubiquitin [Determine 3(B) II and III] although fragment-I has a sixteen amino acid insert and fragment-IV has GV at C-terminal (in place of G in ubiquitin). It is fairly probably that fragment-









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Nonetheless, interaction among mitochondria and the nucleus may possibly affect a lot of mobile pursuits [52], and has been referred to as ``mitochondrial retrograde signaling''. Signaling pathways recognized to be included in this interaction are the concentrate on of rapamycin (TOR) and calcium signaling. Thus, we speculate that mitochondrial retrograde signaling could be concerned in the impai
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